Publications
Zhou, Y., Hou, D., Cusco Marigo, C., Bonelli, J., Rocas, P., Cheng, F., Yang, X., Rocas, J., Hamberg, N. M., & Han, J. (2022). Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis. IScience, 105390. https://doi.org/10.1016/j.isci.2022.105390
Zhou Y, Wan X, Seidel K, Zhang M, Goodman JB, Seta F, Hamburg N, Han J. Aging and Hypercholesterolemia Differentially Affect the Unfolded Protein Response in the Vasculature of ApoE-/- Mice. J Am Heart Assoc. 2021 09 21; 10(18):e020441. PMID: 34533042; PMCID: PMC8649520; DOI: 10.1161/JAHA.120.020441;
Seidel K, Wan X, Zhang M, Zhou Y, Zang M, Han J. Alcohol Binge Drinking Selectively Stimulates Protein S-Glutathionylation in Aorta and Liver of ApoE-/- Mice. Front Cardiovasc Med. 2021; 8:649813.View Related Profiles. PMID: 33796575; PMCID: PMC8007763; DOI: 10.3389/fcvm.2021.649813;
Matsui R, Ferran B, Oh A, Croteau D, Shao D, Han J, Pimentel DR, Bachschmid MM. Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. Antioxid Redox Signal. 2020 04 01; 32(10):677-700.View Related Profiles. PMID: 31813265; PMCID: PMC7047114; DOI: 10.1089/ars.2019.7963;
Weinberg EO, Ferran B, Tsukahara Y, Hatch MMS, Han J, Murdoch CE, Matsui R. IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages. PLoS One. 2019; 14(1):e0210827.View Related Profiles. PMID: 30682073; PMCID: PMC6347181; DOI: 10.1371/journal.pone.0210827;
Song W, Zhou L, Kot KL, Fan H, Han J, Yi J. Measurement of flow-mediated dilation of mouse femoral artery in vivo by optical coherence tomography. J Biophotonics. 2018 11; 11(11):e201800053.View Related Profiles. PMID: 29855165; PMCID: PMC6226329; DOI: 10.1002/jbio.201800053;
Edenbaum H, Han J. Assessment of S-Glutathionylated Rac1 in Cells Using Biotin-Labeled Glutathione. Methods Mol Biol. 2018; 1821:155-163. PMID: 30062411
Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017 Aug 20; 27(6):313-327.View Related Profiles. PMID: 27958883; PMCID: PMC5563925; DOI: 10.1089/ars.2016.6716;
Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YMW, Matsui R, Zang M, Hamburg NM, Cohen RA. The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol. 2016 Oct; 9:306-319.View Related Profiles. PMID: 27693992; PMCID: PMC5045950; DOI: 10.1016/j.redox.2016.09.003;
Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64.View Related Profiles. PMID: 26927696; PMCID: PMC4899292; DOI: 10.1097/FJC.0000000000000381;
Luo T, Nocon A, Fry J, Sherban A, Rui X, Jiang B, Xu XJ, Han J, Yan Y, Yang Q, Li Q, Zang M. AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity. Diabetes. 2016 Aug; 65(8):2295-310.View Related Profiles. PMID: 27207538; PMCID: PMC4955985; DOI: 10.2337/db15-1122;
Chacko AM, Han J, Greineder CF, Zern BJ, Mikitsh JL, Nayak M, Menon D, Johnston IH, Poncz M, Eckmann DM, Davies PF, Muzykantov VR. Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. ACS Nano. 2015 Jul 28; 9(7):6785-93. PMID: 26153796; PMCID: PMC4761649; DOI: 10.1021/nn505672x;
Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Control Release. 2015 Jul 28; 210:39-47. PMID: 25966362; PMCID: PMC4793278; DOI: 10.1016/j.jconrel.2015.05.006;
Murdoch CE, Shuler M, Haeussler DJ, Kikuchi R, Bearelly P, Han J, Watanabe Y, Fuster JJ, Walsh K, Ho YS, Bachschmid MM, Cohen RA, Matsui R. Glutaredoxin-1 up-regulation induces soluble vascular endothelial growth factor receptor 1, attenuating post-ischemia limb revascularization. J Biol Chem. 2014 Mar 21; 289(12):8633-44.View Related Profiles. PMID: 24482236; PMCID: PMC3961686; DOI: 10.1074/jbc.M113.517219;
Shao D, Fry JL, Han J, Hou X, Pimentel DR, Matsui R, Cohen RA, Bachschmid MM. A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress. J Biol Chem. 2014 Mar 14; 289(11):7293-306.View Related Profiles. PMID: 24451382; PMCID: PMC3953247; DOI: 10.1074/jbc.M113.520403;
Greineder CF, Chacko AM, Zaytsev S, Zern BJ, Carnemolla R, Hood ED, Han J, Ding BS, Esmon CT, Muzykantov VR. Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor. PLoS One. 2013; 8(11):e80110. PMID: 24244621; PMCID: PMC3828233; DOI: 10.1371/journal.pone.0080110;
Shuvaev VV, Han J, Tliba S, Arguiri E, Christofidou-Solomidou M, Ramirez SH, Dykstra H, Persidsky Y, Atochin DN, Huang PL, Muzykantov VR. Anti-inflammatory effect of targeted delivery of SOD to endothelium: mechanism, synergism with NO donors and protective effects in vitro and in vivo. PLoS One. 2013; 8(10):e77002. PMID: 24146950; PMCID: PMC3795626; DOI: 10.1371/journal.pone.0077002;
Han J, Zhang G, Welch EJ, Liang Y, Fu J, Vogel SM, Lowell CA, Du X, Cheresh DA, Malik AB, Li Z. A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood. 2013 Dec 12; 122(25):4140-9. PMID: 24108461; PMCID: PMC3862279; DOI: 10.1182/blood-2013-03-491423;
Han J, Zern BJ, Shuvaev VV, Davies PF, Muro S, Muzykantov V. Acute and chronic shear stress differently regulate endothelial internalization of nanocarriers targeted to platelet-endothelial cell adhesion molecule-1. ACS Nano. 2012 Oct 23; 6(10):8824-36. PMID: 22957767; PMCID: PMC3874124; DOI: 10.1021/nn302687n;
Hood ED, Greineder CF, Dodia C, Han J, Mesaros C, Shuvaev VV, Blair IA, Fisher AB, Muzykantov VR. Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo. J Control Release. 2012 Oct 28; 163(2):161-9. PMID: 22974832; PMCID: PMC3495982; DOI: 10.1016/j.jconrel.2012.08.031;
Han J, Shuvaev VV, Muzykantov VR. Targeted interception of signaling reactive oxygen species in the vascular endothelium. Ther Deliv. 2012 Feb; 3(2):263-76. PMID: 22834201; PMCID: PMC5333711; DOI: 10.4155/tde.11.151;
Profirovic J, Han J, Andreeva AV, Neamu RF, Pavlovic S, Vogel SM, Walter U, Voyno-Yasenetskaya TA. Vasodilator-stimulated phosphoprotein deficiency potentiates PAR-1-induced increase in endothelial permeability in mouse lungs. J Cell Physiol. 2011 May; 226(5):1255-64. PMID: 20945373; PMCID: PMC3043150; DOI: 10.1002/jcp.22453;
Han J, Shuvaev VV, Muzykantov VR. Catalase and superoxide dismutase conjugated with platelet-endothelial cell adhesion molecule antibody distinctly alleviate abnormal endothelial permeability caused by exogenous reactive oxygen species and vascular endothelial growth factor. J Pharmacol Exp Ther. 2011 Jul; 338(1):82-91. PMID: 21474567; PMCID: PMC3126647; DOI: 10.1124/jpet.111.180620;
Shuvaev VV, Han J, Yu KJ, Huang S, Hawkins BJ, Madesh M, Nakada M, Muzykantov VR. PECAM-targeted delivery of SOD inhibits endothelial inflammatory response. FASEB J. 2011 Jan; 25(1):348-57. PMID: 20876216; PMCID: PMC3005426; DOI: 10.1096/fj.10-169789;
Feng H, Guo L, Song Z, Gao H, Wang D, Fu W, Han J, Li Z, Huang B, Li XA. Caveolin-1 protects against sepsis by modulating inflammatory response, alleviating bacterial burden, and suppressing thymocyte apoptosis. J Biol Chem. 2010 Aug 13; 285(33):25154-60. PMID: 20534584; PMCID: PMC2919077; DOI: 10.1074/jbc.M110.116897;
Andreeva AV, Han J, Kutuzov MA, Profirovic J, Tkachuk VA, Voyno-Yasenetskaya TA. T-cadherin modulates endothelial barrier function. J Cell Physiol. 2010 Apr; 223(1):94-102. PMID: 20039275; DOI: 10.1002/jcp.22014;
Han J, Liu G, Profirovic J, Niu J, Voyno-Yasenetskaya T. Zyxin is involved in thrombin signaling via interaction with PAR-1 receptor. FASEB J. 2009 Dec; 23(12):4193-206. PMID: 19690217; PMCID: PMC2812041; DOI: 10.1096/fj.09-131862;
Gorovoy M, Han J, Pan H, Welch E, Neamu R, Jia Z, Predescu D, Vogel S, Minshall RD, Ye RD, Malik AB, Voyno-Yasenetskaya T. LIM kinase 1 promotes endothelial barrier disruption and neutrophil infiltration in mouse lungs. Circ Res. 2009 Sep 11; 105(6):549-56. PMID: 19679840; PMCID: PMC3718297; DOI: 10.1161/CIRCRESAHA.109.195883;
Zhang G, Han J, Welch EJ, Ye RD, Voyno-Yasenetskaya TA, Malik AB, Du X, Li Z. Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway. J Immunol. 2009 Jun 15; 182(12):7997-8004. PMID: 19494325; PMCID: PMC2787095; DOI: 10.4049/jimmunol.0802884;